SAPALDIA: Swiss Study on Air Pollution and Lung Disease in Adults

The data of this Swiss large epidemiologic study is an ideal basis for investigating the interplay of genetic and modifiable environmental factors in a broad range of chronic diseases including respiratory, allergic, cardiovascular disease. It is our aim to improve the knowledge of how environmental pollutants impact on the health status of susceptible groups of the general population. This cohort study began in 1991 as a cross- sectional study with the participation of roughly 10’000 adult subjects from eight different Swiss areas having distinct degrees of air pollution exposure and diverse climate. Roughly 80% of the initial participants returned in 2002 for the SAPALDIA follow-up examination and currently the third examination is ongoing.

DNA Bank and Genetic Variation

The blood samples donated by roughly 6000 participants in 2002 constitute the SAPALDIA Biobank. In collaboration with Prof. Dr. Wolfgang Berger (Co-investigator SAPALDIA) and under the lead of Prof. Dr. Nicole Probst-Hensch a SAPALDIA DNA bank was established at the Institute of Medical Molecular Genetics of the University of Zurich. The current research projects investigate the role of the inherited variation present in genes involved in the protection against inflammation and oxidative stress.

Sapaldia Biobank Team:

- Prof. Nicole Probst-Hensch, Dr. phil. II, PhD, Head of Unit Chronic Disease Epidemiology, Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel, Basel. nicole.probst@unibas.ch

- Imboden Medea, PhD, Molecular biologist, Senior Scientist, Chronic Disease Epidemiology, Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel, Basel. medea.imboden@unibas.ch

- Gian Andri Thun, doctoral student, Chronic Disease Epidemiology, Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel, Basel.

- Ivan Curjuric, doctoral student, Chronic Disease Epidemiology, Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Associated Institute of the University of Basel, Basel.

Alumni of the SAPALDIA Biobank Team:

- Esther Glaus, dpl. Biol., Medizinische Molekulargenetik und Gendiagnostik, Insitut für medizinische Genetik, Universität Zürich. Zürich

- Oliver Senn, Dr. med., University Hospital Zürich, Zürich.